glp-1 drugs for addiction Popular Weight-Loss May Also Treat GLP-1 Weight-Loss Drugs Could Address
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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Lpez M, Diguez C, Nogueiras R
In the pancreas, GLP-1RAs are well known to promote insulin secretion
At 12 mg over 68 weeks, weight loss reached 28.7%
Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which typically diminish over time
The study indicates that the process is due to the transdifferentiation between islet cells, and the intestine-islet GLP-1/GLP-1R/PKA signal pathway is one of the important pathways to produce this process ( GLP-1 is one of the hormones responsible for the incretin effect, and exerts a wide variety of actions such as potentiation of glucose-stimulated insulin secretion, reduction of appetite, delay of gastric emptying and inhibit cell dysfunction (Yu et al., 2015
This association may be due to shared pathological mechanisms, including insulin resistance, chronic inflammation, and mitochondrial dysfunction (12)
