moa of glp 1 Mechanism action of GLP-1 agonists – My Endo Consult Glucagon-like peptide 1 (GLP-1) -

In animal studies, administration of dexamethasone caused a reduction of GLP-1 secretion from the intestinal L cells [80] and also decreased the circulating levels of this peptide, which led to glucose intolerance and peripheral insulin resistance in rats [81]

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Association between glucagon-like peptide-1 receptor gene polymorphism and treatment response to GLP1R agonists in Chinese patients with type 2 diabetes: A prospective cohort study

Some laboratory studies suggest that GLP-1 analogues may modulate these neurotransmitter systems, potentially affecting cognitive performance and impulsivity, though these findings remain largely preclinical