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If the ice packs lasted 24-30 hours (which is typical), the medication may have been without active cooling for 14-20 hours
If side effects are problematic, dose adjustment or alternative management strategies can often be implemented
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2022 Dec;65(12):1925-1966
Heart Rate Changes Dose-dependent increases in heart rate peaked at 24 weeks and declined thereafter in clinical trials
[20] mhra.gov.uk or through the Yellow Card app
