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This approach allowed us to explore broad themes such as the effects of GLP-1 RAs on osteoblast and osteoclast activity, bone formation and resorption, and the overall impact on bone integrity and healing

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A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes (SURPASS-CVOT)

Real-world gap (-5 to -7 percentage points), dose-caution from the dysesthesia label (-2 to -4 percentage points), and cost-driven discontinuation (-3 to -5 percentage points of the persistence-adjusted average) together bring the realistic population-mean one-year weight loss on Retatrutide to roughly 17-22%

Tirzepatide is for people who are obese or overweight with a body mass index (BMI) greater than 30