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FDA has documented over 400 adverseevent reports with compounded semaglutide and 300 with compounded tirzepatide, though the Alliance for Pharmacy Compounding disputes the reliability of those data
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July 2024 Study Links Active Ingredient in Some GLP-1 Drugs to Vision Loss A new study published in the Journal of the American Medical Associations Ophthalmology linked semaglutide drugs to a type of eye strokes called nonarteritic anterior ischemic optic neuropathy (NAION)

There are also effects on satiety via actions within the brain

[DOI] [PubMed] [Google Scholar] 7.Nauck M.A., Kleine N., rskov C., Holst J.J., Willms B., Creutzfeldt W

Thus, these neurons are able to sense and respond to a variety of peripheral signals that help to regulate both short and long-term energy balance
