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Participants receiving GLP-1 RAs had a higher BMI (e.g

Tirzepatide is a synthetic peptide medication derived from the structure of human gastric inhibitory polypeptide (GIP), engineered to activate both GIP and glucagon-like peptide-1 (GLP-1) receptors

Bupropion may increase dopamine-mediated testosterone activity, while rapid weight loss from tirzepatide affects testosterone levels through changes in fat tissue aromatase activity and sex hormone binding globulin levels

Lack of LepRb-Tyr985 signaling enhances whole-body insulin sensitivity partly through increased suppression by insulin of hepatic glucose production

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The Bigger Picture: HSAs and Expanded Eligibility Support GLP-1 Affordability Many employees paying for GLP-1s rely on HSAs to cover these drugs tax-free to lower out-of-pocket costs