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Glucose-lowering medications, glycemia, and cognitive outcomes: the GRADE randomized clinical trial

Tirzepatide may be the better choice if: You need to lose 15% or more of your body weight

Common Side Effects Both medications cause primarily gastrointestinal effects: Saxenda common side effects: Nausea (39%) Diarrhea (21%) Constipation (19%) Vomiting (16%) Injection site reactions (14%) Headache (14%) Dyspepsia (10%) Semaglutide common side effects: Nausea (44%) Diarrhea (30%) Vomiting (24%) Constipation (24%) Abdominal pain (20%) Headache (14%) Fatigue (11%) Side Effect Comparison Table Interpreting the Numbers Semaglutide appears to have higher rates of GI side effects in clinical trials

1 Sustained weight loss of 5-10% has been shown to significantly reduce the risk of developing obesity-related comorbidities, with the risk of developing diabetes reduced by up to 60% in overweight and obese adults who sustained weight loss for at least two years

The dosing rationale was determined from the pharmacokinetic profile of mGIPR-Ab following a single ICV-administered dose (Extended Data Fig

If Metamucil (psyllium husk) causes too much bloating on Ozempic, Wegovy, Zepbound, Mounjaro, or Retatrutide , many people assume switching to "gas-free" Citrucel is the safe alternative