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These medications are based on GLP-1 receptor agonists, such as semaglutide (found in Wegovy and Ozempic), which help regulate appetite and blood sugar levels

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When we treated the slices with 100 nM tertiapin-Q, a GIRK channel blocker, membrane potential was depolarized by 2.90.3 mV (from 52.42.1 to 49.51.9 mV, n =4) in four of seven POMC neurons (50%) (Fig

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