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Lets talk about what we actually know: The Biology: GLP-1 receptors are expressed throughout the body, including on immune cells, endothelial cells (lining blood vessels), neurons, and adipose tissue

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The medication also appears to have beneficial effects on the gut, including possible effects on the gut microbiome and intestinal glucose handling, though these mechanisms are still being fully elucidated

Basics of meta-analysis: I2 is not an absolute measure of heterogeneity

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The Brookings Institution, a research think tank, published a report in April on research labs selling counterfeit GLP-1s to Americans