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However, retatrutide has not received FDA approval

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White, Dipeptidyl Peptidase-IV Inhibitors: Pharmacological Profile and Clinical Use, Clin

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76 Thus, since PI3K/Akt is activated by both cAMP-dependent and cAMP-independent pathways, there is likely context-dependent variability in GLP-1R signaling, influenced by cell type, receptor architecture, and duration of stimulation
