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N Engl J Med (2022) 387(12):106374

You may also have heard about people buying them in Mexico and Canada, but this is strongly discouraged by doctors because of the lack of regulation and safety checks, and the potential for fake drugs

The Lancet , 397 (10286), 1736-1748

The mean changes from baseline to week 26 were -0.9 kg and -3.4 kg in the placebo and RYBELSUS 14 mg arms, respectively
You notice oral lesions, persistent dry mouth, or signs of oral infection alongside taste changes, which may require specific treatment

Semaglutide 2.4 mg (Wegovy) is the next most effective option
