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Benefits and Harms of Once-Weekly Glucagon-like Peptide-1 Receptor Agonist Treatments: a Systematic Review and Network Meta-analysis

Na kraju, ali ne i najmanje bitno, postavlja se pitanje da li Retatrutid za mravljenje zaista reava problem gojaznosti, kao i ostalih metabolikih stanja, odnosno oboljenja povezanih sa gojaznou (dijabetes, visok krvni pritisak, masna jetra)

NICE guidance (NG28) on type 2 diabetes management recognises GLP-1 receptor agonists as effective second- or third-line therapies, particularly for patients with obesity or those requiring additional glycaemic control

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While conducting studies to test this may be difficult, the few studies that have looked at the number of affected relatives have found a dose-response type relationship, where increasing number of relatives affected increases the risk of heart disease

for some [dulaglutide (Gerstein et al., 2019), liraglutide (Marso et al., 2016) and semaglutide (Marso et al., 2017)], the CVOTs also confirmed a cardiovascular benefit and eventually led to the approved use of these GLP-1 RAs to reduce cardiovascular risk in people with type 2 diabetes and established CVD or at high cardiovascular risk (Honigberg et al., 2020)