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In preclinical data, creatine appears to play some role in browning adipose tissue, and a human study found creatine increased resting metabolic rate, indicating potential weight management benefits [65,66]

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This review identified key mechanisms, including CCK suppression, disruption of FXR and TGR5 signaling, and alterations in bile acid composition, that may contribute to impaired gallbladder motility and gallstone formation

118 reported that GLP-1RAs with metformin improved oxidative stress markers, such as IL-6, suggesting a reduction in systemic inflammation

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