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There is no established pharmacologic mechanism by which GLP-1 receptor agonism would directly cause musculoskeletal pain

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Tesamorelin produces a preferential reduction in visceral fat through GH-mediated lipolysis, with minimal effect on total body weight

Testosterones anabolic role in skeletal muscle is mechanistically well supported, spanning androgen receptor-mediated transcription, protein synthesis signaling, and effects on muscle regeneration and quality [10,11,12,29]