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Nanoplatforms contribute to obesity therapy by enhancing drug delivery, extending pharmacokinetic half-life, and maintaining continuous GLP-1R stimulation, which is essential for sustained weight loss [235]

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In line with this expectation, GLP-1R agonists, including exendin-4, have been shown to exhibit antidepressant properties, independently of weight loss, in preclinical studies (95-97)
Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls

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