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Keeping a symptom journal during tirzepatide treatment helps distinguish between medication effects, coincidental illness, and indirect consequences of the metabolic changes the drug produces

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Kidney function may require attention when gastrointestinal symptoms create a risk of significant fluid loss

Animals were cared for in accordance with the Guide for the Care and Use of Laboratory Animals , 8 th edition

The reviews generally conclude that gut microbiome modulation may contribute to the metabolic benefits of GLP-1 receptor agonists, and that probiotics may complement these effects

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