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* Indication: Improve glycemic control as an adjunct to diet and exercise * Important Note: Contraindications: - Not for patients with a history of medullary thyroid carcinoma

Being placed on the FDAs drug shortage list has prompted an explosion of compounding pharmacies offering GLP-1s

Oral Electrolyte Solutions: If vomiting occurs, its vital to replenish lost fluids and electrolytes

Resources on peptides for depression and anxiety and peptides for brain repair provide additional context on how various peptides interact with neurological function

The most common gastrointestinal side effects include: Nausea : Reported in 15-44% of patients (higher rates at Wegovy 2.4 mg), typically most pronounced during dose escalation Diarrhea : Affects approximately 8-30% of users, ranging from mild to moderate severity Vomiting : Occurs in 5-24% of patients (higher rates at Wegovy 2.4 mg), often associated with rapid dose increases Abdominal pain : Experienced by 5-20% of patients, usually described as cramping or discomfort Constipation : Paradoxically affects 3-24% despite the medication's effects on motility Dyspepsia and gastroesophageal reflux : Related to delayed gastric emptying These effects result from semaglutide's pharmacologic action on GLP-1 receptors throughout the gastrointestinal tract

GLP-1 achieves its roles by binding to its specific receptor (GLP-1R) on human hepatocytes [9]