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A HOMER motif enrichment analysis identified potential regulatory factors driving these transcriptional changes, with transcription factors for upregulated genes including FOXO3, OCT4, and TBX5, and those for downregulated genes including HRE, NPAS4, and TWIST ( Figure S6E )

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The objective was to evaluate the effectiveness and safety, with a specific focus on cardiovascular safety, of tirzepatide, a novel dual GIP and GLP-1 receptor agonist, compared to insulin glargine in adults with type 2 diabetes and a high risk of cardiovascular events who have not achieved adequate control with oral glucose-lowering medications.This phase 3 study was conducted at 187 sites across 14 countries on five continents

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Tamhane, S., Rodriguez-Gutierrez, R., Hargraves, I
