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Recently, to ensure the safety of GLP-1 RA on sarcopenia, a clinical randomized multicenter trial of bimagrumab, an antibody blockade of activin type II receptor inhibitor, alone or in addition to subcutaneous semaglutide is now ongoing (NCT05616013) [113]
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However, the drug regulatory authorities have also documented rare and occasional severe side effects associated with using GLP-1 agonists, especially GI disease

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These gastrointestinal effects may overlap with or exacerbate existing IBS symptoms, particularly during treatment initiation

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