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Aging Cell (2015) 14:9213
N Engl J Med 2023;389:222132.ArticlePubMed 40
doi:10.3389/fimmu.2023.1148209 102
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If obesity-related complications are already present, pharmacologic treatment should be considered as first-line, in combination with lifestyle therapy, without the need to delay until lifestyle interventions alone are attempted
However, the protocol did not mandate a specific calorie deficit for participants diets, to allow for a more flexible approach to weight management [2]
