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A 2024 KFF survey revealed that about 1 in 8 American adults have tried a GLP-1 agonist, which works by mimicking a natural hormone in the body that regulates insulin and blood sugar levels while promoting feelings of fullness, helping the average patient shed 10% to 15% of their body weight

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The idea of regulating glucose levels through DPP-4 inhibition was initially conceived 25 years ago, paving the way for the development of different DPP-4 inhibitors and their widespread clinical utilization [38]

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes and obesity, have evolved into multi-organ potential therapeutics due to their pleiotropic effects beyond glycemic control

Last reviewed: May 21, 2026 Last updated: May 21, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Thus, it is clear that hepatic glucose metabolism is improved in patients with or without T2DM after surgery