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The side effect profiles overlap heavily in the GI department, nausea, constipation, reduced appetite, but semaglutide lacks the glucagon receptor activation that gives retatrutide its thermogenic edge

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On the other hand, patients with a lower BMI may have a better chance of maintaining their weight loss through other means

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Cell 153:11941217 Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2