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In: Avers D, Wong RA, editors

Therefore, grapefruit should be avoided by those taking such medications

pathogenic variants in leptin ( LEP ), leptin receptor ( LEPR ), POMC , prohormone convertase 1 ( PCSK1 ), melanocortin 3 and 4 receptors ( MC3R and MC4R ), and SH2B1 all lead to dysregulated energy homeostasis and hyperphagia secondary to defective hypothalamic signaling [33, 34]
2022a, b, c
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An individual with a BMI score of 25 or above falls into the overweight category, whereas someone with a BMI of 30 or higher would be considered obese
