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Meg Tirrell 00:23:00 'I think there are still a lot of folks who feel that way

The variability in trial durations, ranging from 3 to 12 weeks across the included studies, and differences in the number of titration steps for each drug may further influence the reported incidence of gastrointestinal adverse events, particularly for agents like tirzepatide, where nausea risk escalates with higher doses (e.g., OR = 4.36, 95% CI: 3.425.61 at 10 mg) (Liu et al., 2025)

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PlexusDx supports clinical decision-making with genetic-pathway context, but serious adverse events require immediate provider contact regardless of platform

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These may not be FDA-approved, and they can create safety uncertainty