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This study was conducted by utilizing EHR data before the release of FLOW trial results

8,12,13 A meta-analysis by Ku and Chang 6 reported PASI improvement in both diabetic and nondiabetic groups (over the 6- to 12-week periods of the 4 prospective cohort studies analyzed), with nearly 35% achieving a 75% or greater improvement in PASI (PASI-75) from their respective baselines, and a proposed immunomodulatory mechanism

Therefore, the weight reduction efficacy of GLP-1RAs in the overweight/obese BMI studies may be narrowed down by these weight-losing comparator agents

A prospective trial assessing clinical outcomes across different stages of fibrosis in MASLD showed parallel increases in liver adverse outcomes and all-cause mortality with fibrosis severity