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doi: 10.1007/s00394-004-0448-4

Absolute risk increase approximately 0.7 percentage points

Cardiovascular and metabolic benefits Beyond weight loss and pain relief, retatrutide delivered additional health improvements

Renal function decline as GLP-1 and GIP agonists can cause nausea, diarrhoea and vomiting, this may result in dehydration and associated reduction in renal function

It is a property peptide agonists do not share GLP-1 and its peptide mimetics activate rodent receptors perfectly well, which is why decades of incretin biology were worked out in standard rodent models

NICE has not issued guidance as no marketing authorisation has been granted