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The first is the impact of the drugs on appetite

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Amelioration of muscle wasting by glucagonlike peptide1 receptor agonist in muscle atrophy

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As of 2022, GLP-1RAs have been recommended as first-line treatments, along with SGLT-2 inhibitors, for patients with T2DM and cardiovascular disease in American Diabetes Associations Standards of Medical Care in Diabetes (248, 249)

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10.1016/j.brainres.2005.08.053 96 TakedaN.HasegawaS.MoritaM.MatsunagaT

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Treatment with an AOM often follows a pattern of initial weight loss that tends to level out, or plateau, after a period of time on treatment [54, 56, 57]

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