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Updated timeline: May 2026: TRIUMPH-1 Phase 3 topline results announced Late 20262027: Remaining TRIUMPH trials complete

Furthermore, leptin receptor-deficient mice, a mouse model of obesity and diabetes, and people with endogenous glucagon deficiency (pancreatectomised individuals) treated with glucagon antisense oligonucleotide have increased hepatic fat [52, 53]

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doi: 10.1007/s00125-005-0128-9 49 NishiHHigashiharaTInagiR

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Furthermore, the increased molecule size resulting from IgG4-Fc linkage reduces the elimination rate92)