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But the additional GIP receptor binding domain makes tirzepatide a fundamentally different pharmacological tool

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Future directions Considering the GLP-1 RAs currently available for treating T2DM and obesity, along with the numerous new GLP-1 RAs, dual, and triple agonists in development, we anticipate a shift in clinical practice towards more personalized and tailored use of these agents to meet individual patient needs

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We next assessed mitochondrial metabolism of glucose and palmitic acid by measuring the oxygen consumption rate (OCR)