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GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

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Completers on liraglutide 2.4/3.0mg (n=92) maintained a 2-year weight loss of 7.8kg from screening

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