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The MHRA regulates the approval of new medicines in Great Britain following the UK's departure from the European Union, whilst the EMA retains responsibility for authorisation across EU member states

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This requirement underscores the variability in coverage, as some arrangements may not mandate this documentation

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That will trend down to the same $245 over 24 months, an official said, with under-development oral medications, should they be approved, starting at $149 for the lowest dose

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The discussion highlights challenges in PE trial design, the critical importance of clinical deterioration as an endpoint, and why this era represents an unprecedented wave of evidence generation in PE

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