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After a 4-week run-in period in which participants were treated with diet and exercise alone, those who fulfilled the randomisation criteria were randomised (1:1:1:1) using a web-based randomisation system to receive once-daily oral semaglutide 3 mg, 7 mg or 14 mg or placebo for 26 weeks (using a 4-week dose-escalation regimen for the higher doses)

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If you are an adult living with kidney disease and excess weight or obesity, you may be eligible to join a trial studying the impact of tirzepatide on kidney function

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However, if you are already taking insulin or a sulfonylurea, your prescriber may need to adjust your diabetes medication to reduce the risk of hypoglycaemia