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Weeks 1-4: 0.25mg weekly subcutaneous injection Weeks 5-8: 0.5mg weekly subcutaneous injection Weeks 9-12: 1.0mg weekly subcutaneous injection Weeks 13+: 1.0mg maintenance or increase to 1.7-2.4mg based on response The starting dose of 0.25mg per week produces minimal appetite suppression but allows gastrointestinal adaptation
You should see a doctor if you experience any new or worsening vision changes, such as: blurred vision dark spots flashes of light sudden vision loss For people without diabetes or without existing eye disease, eye-related side effects are considered very unlikely

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Calcineurin inhibitors (CNIs), the cornerstone of immunosuppression in liver transplant recipients, are a significant contributor to worsening pre-existing diabetes and contributing to development of PTDM
