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The medication is administered once weekly via subcutaneous injection, with doses typically initiated at 2.5 mg once weekly for 4 weeks, then escalated (e.g., to 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg) based on response and tolerability as per the SmPC

STEP-4 gave every participant a 20-week course of semaglutide 2.4 mg once weekly, and produced a mean weight loss of 10.6%, before randomisation to either continued semaglutide treatment or exchange to placebo for an additional 48 weeks
