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Description
Comparison with Semaglutide, Liraglutide, and Dulaglutide While semaglutide and liraglutide activate GLP-1 receptors alone, tirzepatide's dual receptor action yields greater HbA1c reductions and more profound weight loss
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In clinical trials, gastrointestinal adverse events occurred in 37-48% of patients (depending on dose), with higher rates at higher doses

Since tirzepatide already activates the GLP-1 receptor along with the GIP receptor, combining it with semaglutide could overstimulate these pathways

This timing maximises endogenous GH secretion while minimising cortisol elevation, which can occur with poorly timed sermorelin doses

, we must examine the Hypothalamic-Pituitary-Gonadal (HPG) axis
