nature medicine semaglutide Long-term weight loss effects of in obesity without diabetes in the SELECT trial Could GLP-1 Weight Loss Drugs

BMI 28-29: 5 mg

Nausea on Ozempic or Wegovy

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Hepatic Effects: Semaglutide has been shown to reduce liver fat content in patients with non-alcoholic fatty liver disease (NAFLD), possibly through improvements in insulin sensitivity and lipid metabolism

Key implications: Simplified administration may improve patient uptake Broader accessibility across diverse healthcare settings Reinforces the shift toward chronic disease models in obesity care As we move forward, the focus will not only be on efficacy but also on real-world implementation, cost considerations, and long-term outcomes

Fibrosis, characterised by the excessive deposition of extracellular matrix via activated fibroblasts, is a pathological feature of several chronic inflammatory disorders, which collectively contribute significantly to global morbidity and mortality