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The landmark PREDIMED trial -- a randomized controlled trial involving 7,447 participants -- demonstrated that a Mediterranean diet supplemented with EVOO (approximately 50 g/day) did not result in weight gain over nearly five years of follow-up, despite being an unrestricted-calorie, high-fat diet (Estruch et al., 2018)

This hormone plays a key role in regulating blood sugar levels, appetite, and digestion

Some people also experience an impact on physical feelings of hunger and an impact on eating habits associated with reward (for example reduced pleasure in eating high-fat or sugary foods)

Semaglutide is also available as Rybelsus , which is approved for type 2 diabetes and can be prescribed off-label for weight loss

All Simple Peptide products are labeled Research Use Only (RUO) and are intended strictly for laboratory, investigational, and scientific research purposes

"More Than 20% Weight Reduction in Individuals With Obesity"