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Front Pharmacol (2020) 11:356

During the 3 months before or 3 months after becoming pregnant, about 15,000 of those individuals filled a prescription for a first- or second-line noninsulin antidiabetic medication

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The other authors declare no conflicts of interest relevant to this paper

Evidence demonstrates that acute glucose fluctuation forms the stress that alters microglial activity (eg, inflammatory activation or self-degradation), which may be one of the mechanisms of cognitive deterioration in diabetic patients