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two in the control group, without any significant difference between the groups (6.8% vs

Dose-dependent increases in fasting insulin and C-peptide were observed, with maximum levels seen at 24 and 48 hours, returning to near baseline levels by Day 15

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More broadly, there are certain situations in which you should seek prompt medical advice, regardless of whether you are on an investigational medication: Symptoms of a UTI that do not improve within 48 hours contact your GP or use NHS 111 Fever (38C or above), rigors (shivering), or back/flank pain these may indicate a kidney infection (pyelonephritis) and warrant same-day medical assessment

Stay ahead of side effects Do not wait for nausea to become unbearable before adjusting your approach