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These efforts have led to the development of various GLP-1 receptor agonists, the most recent being semaglutide and tirzepatide, approved for the treatment of type 2 diabetes in 2018 and 2022, respectively

[DOI] [PubMed] [Google Scholar] 54.Caruso I, Di Gioia L, Di Molfetta S, et al

Both have generated extraordinary interest in clinical and research communities for their ability to influence body weight, blood glucose regulation, and metabolic function but they work through fundamentally different pathways and show very different results

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