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3, 2025, p.m

25 Given concerns that skeletal muscle loss may predispose patients to long-term metabolic complications, including sarcopenia, it is recommended that individuals undergoing treatment with GLP-1 RAs receive adequate protein intake and appropriate micronutrient supplementation to preserve muscle mass and function, thereby maximizing the clinical benefits of therapy

Its also harder to get approval to become a candidate for bariatric surgery

Manufacturers and lactation experts recommend caution due to theoretical risks, unknown infant metabolic effects, and lack of safety data in vulnerable populations

A real-world prospective study of 105 patients who completed 12 months of GLP-1RA therapy found that those transitioning to generic medications with a weight-lowering effect maintained a mean total weight loss of 25.5% at approximately 593 days, with metformin being utilised in 80% of this cohort