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Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: an updated systematic review and meta-analysis including the latest SURMOUNT-2 trial

Their finding marked a decisive breakthrough because it challenged a long-standing belief that nerves controlled the secretion of digestive enzymes that had grown out of the work of Ivan Pavlov, the Russian physiologist who demonstrated that dogs can be conditioned to salivate by the sound of a bell (Rehfeld 2012)

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[35] Medical uses [edit] European Union [edit] In the European Union, semaglutide is indicated for the treatment of adults with insufficiently controlled type 2 diabetes as an adjunct to diet and exercise as monotherapy when metformin is considered inappropriate due to intolerance or contraindications, [16] [17] in addition to other medicinal products for the treatment of diabetes

Proposed mechanisms include physical compression of vessels and nerves, induction of glomerular hyperfiltration (48), and activation of the RAAS as well as stimulation of inflammation by local release of cytokines (49)