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Endocrine regulation of central GLP-1 secretion As discussed above, in addition to enteroendocrine L-cells, GLP-1 is also produced in a discrete set of non-TH-positive neurons in the caudal portions of the NTS [86,148,[346], [347], [348]], and these hindbrain GCG + positive neurons are the primary source of endogenous brain GLP-1 [90]

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The most pronounced delay is observed with short-acting agents, while long-acting agents (including both oral and injectable) show attenuation of this effect over time due to tachyphylaxis [20,21,22]

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