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This work provides an important advance in our understanding of the decline in -cell proliferation that occurs with aging and indicates that even pharmacological GLP-1 signaling may not be critical in driving proliferation in humans

This PWA model mimics a subtype of PCOS patients that exhibit chronic hyperandrogenism, with marked metabolic, hormonal, and reproductive/gonadal alterations, which represent the majority of cases

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It's worth noting that GLP-1 isn't a hormone replacement and won't address symptoms like hot flushes or night sweats that are directly caused by oestrogen decline

Support for bone and muscle health, particularly important given association between obesity, GLP-1 use, and inadequate micronutrient intakes