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The MHRA-approved schedule follows a four-step escalation over roughly three months: A prescriber may extend any step if side effects need more time to settle

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Including the change in body weight in the analysis negated the blood pressure effect of semaglutide, suggesting that the effect is at least partly mediated by weight loss

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Some women with polycystic ovary syndrome (PCOS) have reported improved menstrual regularity whilst taking GLP-1 medications, though this is likely related to weight loss and improved insulin sensitivity rather than a direct pharmacological effect on ovarian function