does semaglutide increase your metabolism GLP-1 vs. GLP-1 + GIP: What's the Difference for Metabolism? If I Stop Semaglutide Will

It improved somewhat when I lowered my dose in months 5-6

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29-31 Anam et al

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In the Phase 2 obesity trial, retatrutide 12 mg produced approximately 24.2% mean weight loss at 48 weeks ( Jastreboff et al., NEJM 2023 ), and the Phase 2 type 2 diabetes trial showed strong HbA1c and weight reductions ( Rosenstock et al., Lancet 2023 )

However, because the brain uses the same dopamine pathways for other rewards (like shopping, alcohol, or even social interaction), some researchers believe the drug may act as a general reward dampener