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This involves slowly reducing the dose over time to minimize withdrawal effects and weight regain

Derek Thompson: How long did it take Lilly to recognize that what had begun as a type 2 diabetes drug was in fact an incredibly powerful weight-loss drug

I don't think the way the FDA has done this has been productive. The APC, which represents over 600 compounding pharmacies in the US, has sent a letter to the FDA urging it to use enforcement discretion and allow compounders an extended off-ramp to help transition patients

However, previous large-scale trials comparing intensive versus standard glycemic control, such as ACCORD and ADVANCE, demonstrated that while intensive glucose lowering modestly reduced the incidence of nonfatal MI, it did not significantly reduce CV mortality among patients with T2D (70, 72, 73)

Given ongoing concerns regarding suicidality, future trials should incorporate rigorous adverse event monitoring, especially for individuals concurrently using psychotropic medications, to ensure safe prescribing practices and inform regulatory oversight as GLP1RA use continues to expand

It targets the abuse of compounding practices for large-scale profit at the expense of patient safety