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Anatomy of the normal upper gastrointestinal tract (left) and after Roux-en-Y gastric bypass and sleeve gastrectomy
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Network meta-analyses demonstrate a progressive efficacy gradient: GLP-1 monotherapy achieves approximately 7 kg weight reduction, dual agonists reach 11 kg, while triple agonists achieve up to 24 kg weight loss at 52 weeks [77]
At higher concentrations, the peptide molecules are packed more closely together, which can increase the rate of aggregation under thermal stress
There are currently no specific agents for NAFLD [103]
