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Vitamin B6 (pyridoxine) at 2550 mg daily has been used in pregnancy-related nausea research and may help some semaglutide users, though evidence specific to GLP-1 therapy is limited

Scott Butsch, MD, explains why its not a recommended practice

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However, as the disease progresses, some individuals may develop digestive complaints alongside other symptoms such as fatigue, right upper abdominal discomfort, or general malaise

[3] It is important to distinguish correlation from causation

Is it normal to feel fatigued on semaglutide