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It was inspired by a fascinating discovery: the Gila monster, a venomous lizard from the American Southwest, produces a compound in its saliva called exendin-4

Finally, the major population of TriNetX database is the white population and we excluded distinctions for some racial groups like the Hispanic ethnicity, thus the generalizability of our results may be low especially for the non-white populations considering the existing differences in disease prevalence and healthcare access across groups/ethnicities

Pasqua MR, Tsoukas MA, Kobayati A, Aboznadah W, Jafar A, Haidar A

If your response plateaus at 5 mg, your prescriber may jump straight to 10 mg, skipping 7.5 mg

The STEP 1 clinical trial showed participants on 2.4 mg semaglutide lost an average of 14.9% of body weight over 68 weeks

The proportion of female participants was similar across groups, comprising 45.3% in the GLP-1RA group and 45.5% in the DPP-4i group (SMD = 0.0044), and 41.7% and 42.2% in the GLP-1RA and SGLT-2i cohorts, respectively (SMD = 0.0114)